Baclofen toxicity

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  • Baclofen is a synthetic derivative of GABA that can be used for conditions such as multiple sclerosis or muscle spasticity
  • At therapeutic doses, Baclofen acts as a GABA-B receptor agonist
  • At higher doses, Baclofen loses selectivity and can cause sedation
  • Primary excreted by the kidneys

Clinical Features

  • Nausea and vomiting
  • Drowsziness
  • Delirium
  • Seizures
  • Coma
  • Respiratory compromise
  • Hypothermia

Differential Diagnosis

Sedative/hypnotic toxicity


  • Diagnosis of exclusion


  • Activated charcoal for recent ingestion
  • Supportive care:
    • IV fluids, respiratory care
    • Vasopressors for persistent hypotension
    • Benzodiazepines for seizures
  • Hemodialysis for very severe toxicity


See Also


  • Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. Accessed April 29th, 2014.
  • Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82