Limbic encephalitis

Revision as of 18:37, 16 August 2019 by ClaireLewis (talk | contribs) (Created page with "==Background== *Autoimmune encephalitis caused by autoantibodies against intracellular neuronal proteins *Typically not limited to limbic system *Majority of cases are p...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Background

  • Autoimmune encephalitis caused by autoantibodies against intracellular neuronal proteins
  • Typically not limited to limbic system
  • Majority of cases are paraneoplastic, particularly associated with small cell lung cancer, germ-cell testicular tumors, teratomas

Clinical Features

Differential Diagnosis

Altered mental status

Diffuse brain dysfunction

Primary CNS disease or trauma

Psychiatric

Evaluation

  • Diagnosis unlikely to be made in the ED
  • Evaluate for alternative diagnoses
  • MRI Brain- usually increased T2 signal involving one or both temporal lobes.[1]
  • LP- CSF w/lymphocytosis (though usually <100), elevated protein, normal glucose, elevated IgG index, oligoclonal bands[2]

Management

Disposition

  • Admit

See Also

External Links

References

  1. Nicholas, D (2003). "Clinical, Magnetic Resonance Imaging, and 7Electroencephalographic Findings in Paraneoplastic Limbic Encephalitis". Mayo Clinic Proceedings. 78 (11): 1363–1368.
  2. Vincent A, Buckley C, Schott JM, et al. (2004). "Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis". Brain. 127 (3): 701–712
  3. Tüzün E, Dalmau J (2007). Limbic encephalitis and variants: classification, diagnosis and treatment. The Neurologist. 13 (5).
Authors: