Acrodermatitis enteropathica


  • Disorder of zinc metabolism (either congenital mutation, abnormal zinc characteristics in mother's breast milk, or due to surgery affecting upper GI tract) that leads to effective zinc deficiency

Clinical Features

Differential Diagnosis

Vitamin deficiencies


  • Serum zinc level typically low
  • Reduced serum alkaline phosphatase levels often supportive evidence for zinc deficiency, as zinc is a cofactor for alkaline phosphatase activity[1]


  • Zinc sulfate supplementation (13.2 mg/kg/day, totaling ~3mg/kg/day of elemental zinc)
  • Monitor zinc levels every 4-6 months


See Also

External Links


  1. Kiliç I, Ozalp I, Coŝkun T, Tokatli A, Emre S, Saldamli I, Köksel H, Ozboy O. The effect of zinc-supplemented bread consumption on school children with asymptomatic zinc deficiency. J Pediatr Gastroenterol Nutr. 1998 Feb;26(2):167-71. doi: 10.1097/00005176-199802000-00008. PMID: 9481631.