(Redirected from Cortisporin otic)


  • Type: topical antibiotic/steroid
  • Dosage Forms: 3.5 mg/10,000 units/10 mg per mL
  • Routes of Administration: topical, otic
  • Common Trade Names: Cortisporin otic

Adult Dosing

  • 4 drops in ear q6-8hr
  • Max: 10 days

Pediatric Dosing

  • 3 drops in ear q6-8hr
  • Max: 10 days

Special Populations

Renal Dosing

  • Adult: n/a
  • Pediatric: n/a

Hepatic Dosing

  • Adult: n/a
  • Pediatric: n/a


  • Allergy to class/drug
  • Cutaneous viral infection of the external auditory canal (e.g. patients with herpes simplex, vaccinia, and varicella infections)

Adverse Reactions


  • Ototoxicity
  • Neomycin sensitization with itching, reddening, edema, and failure to heal
  • Systemic absorption of topical corticosteroids--> HPA axis suppression --> adrenal crisis
  • Prolonged use of corticosteroids may lead to increase incidence of infection, masking of infection, limited response to vaccines
  • Prolonged use of corticosteroids associated with development of Kaposi sarcoma


  • Itching
  • Redness
  • Rash
  • Swelling

Mechanism of Action

  • Hydrocortisone: Suppresses inflammatory response
  • Polymyxin: disrupts bacterial cytoplasmic membrane permeability allowing leakage of intracellular contents--> bactericidal
  • Neomycin: Inhibits protein synthesis


See Also