Does prehospital LUCAS-2 mechanical CPR improve survival from out-of-hospital cardiac arrest?
The use of LUCAS-2 in non-traumatic, out-of-hospital cardiac arrests did not show improvement over manual CPR in patient survival to 30 days.
- Survival to 30 days had no difference with 6% (LUCAS-2) vs. 7% (control)
- No difference in ROSC, survival of event, survival to 3 months, or survival to 12 months
- Decreased favorable neurologic outcome (CPC 1 or 2) in LUCAS-2 group
Pragmatic, cluster randomized, controlled trial
91 ambulance stations (selected for being urban and semi-urban) from 4 UK National Health Service (NHS) Ambulance Services (West Midlands, North East England, Wales, South Central).
- No major differences in baseline characteristics
- Mean age ~71 years
- 63% male
- ~87% presumed cardiac etiology
- ~82% arrests occurred at home
- ~62% witnessed arrests
- ~44% bystander CPR performed before EMS arrival
- ~6.4 minute response time from call to EMS arrival
- ~82% given IV medications
- ~46% intubated
- ~67% transported to hospital
- Vehicle included in trial is first on scene
- Patient in cardiac arrest outside of a hospital
- Resuscitation attempted
- Known or believed to be ≥18 years of age
- Cardiac arrest caused by trauma
- Known or apparent pregnancy