Multiple endocrine neoplasia

Background

MEN findings by type.
  • Autosomal dominant predisposition to tumors within endocrine organs/glands
  • Classified into two distinct syndromes, multiple endocrine neoplasia type 1 (MEN1), and multiple endocrine neoplasia type 2 (MEN2)
    • Type 2 further subclassified into MEN2A and MEN2B

Clinical Features

Differential Diagnosis

Evaluation

  • MEN1: Should be suspected in any patient with two or more primary MEN1 tumor types
  • MEN2: Should be suspected in any patient with medullary thyroid cancer or pheochromocytoma

Workup

Diagnosis

  • Clinical diagnosis with confirmatory genetic testing
    • MEN1: Germline MEN1 mutation
    • MEN2: Germline RET mutation

Management

Disposition

See Also

External Links

References

  1. Al-Salameh A, Cadiot G, Calender A, Goudet P, Chanson P. Clinical aspects of multiple endocrine neoplasia type 1. Nat Rev Endocrinol. 2021 Apr;17(4):207-224. doi: 10.1038/s41574-021-00468-3. Epub 2021 Feb 9. PMID: 33564173.