Sheehan's syndrome

(Redirected from Sheehan Syndrome)

Background

  • Also known as postpartum hypopituitarism
  • Caused by pituitary hypoperfusion and infarction usually in the setting of postpartum hemorrhage
  • During pregnancy there is enlargement of the pituitary gland predisposing it to ischemia in low-flow states

Clinical Features

Differential Diagnosis

Evaluation

  • Evaluation of serum prolactin levels is not performed as it is difficult to differentiate low from normal serum prolactin levels

Workup

  • Workup should include testing of all anterior pituitary hormones
  • Patients should be evaluated and treated for adrenal insufficiency immediately as this can worsen pre-existing hypotension
  • Other pituitary hormones can be tested for 4-6 weeks after the initial insult

Diagnosis

Management

  • Currently no treatment is available but there is an ongoing small open-label pilot study looking at using recombinant human prolactin

Disposition

See Also

External Links

References