Tetrahydrozyline
Administration
- Type: Adrenergic agonist, decongestant, vasoconstrictor; imidazoline derivative[1][2]
- Dosage Forms: 0.05% solution, 0.1% solution
- Routes of Administration: Nasal, ophthalmic
- Common Trade Names: Tyzine Eye Drops, GoodSense Eye Drops, GoodSense Relief Eye Drops, Opti-Clear, Visine Advanced Relief
Adult Dosing
- Nasal congestion
- 2-4 drops or 3-4 sprays 0.1% solution into each nostril every 3-4 hours as needed
- Ocular decongestant
- 1-2 drops in affected eye up to 4 times a daily
Pediatric Dosing
- Nasal congestion:
- Children 2-6 years: 2-3 drops 0.05% solution into each nostril every 406 hours as needed
- Children >6 years: adult dosing
- Ocular decongestant:
- Children >6 years: adult dosing
Special Populations
Pregnancy Rating
- C
Lactation risk
- Unknown
Renal Dosing
- Adult: N/A
- Pediatric: N/A
Hepatic Dosing
- Adult: N/A
- Pediatric: N/A
Contraindications
- Allergy to class/drug
- 0.5% solution is contraindicated in children <2; 0.1% solution is contraindicated in children <6
Adverse Reactions
Serious
- Coma, bradycardia, respiratory depression, sedation in children with even small (1-1ml) ingestions
Common
- Sneezing, stinging sensation in nose
- Hypertension, palpitations, tachycardia
- Headache
- Tremor
- Blurred vision
Pharmacology
- Half-life: N/A
- Metabolism: N/A
- Excretion: N/A
Mechanism of Action
- Alpha adrenergic agonist - arteriolar constriction